产品名称
IMPDH2 (12M4) Rabbit Monoclonal Antibody
别名
IMPD2; IMPDH 2; IMPDH II; Impdh2;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P12268
免疫原
A synthetic peptide of human IMPDH2
稀释度
WB: 1:1000 IHC: 1:100-1:200 ICC/IF: 1:100-1:200
注意事项
IMPDH2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
IMPDH1 is the main species in normal leukocytes and IMPDH2 predominates over IMPDH1 in the tumor
细胞定位
Cytoplasm. Nucleus. Cytoplasm, cytosol. Note=Can form fiber-like subcellular structures termed 'cytoophidia' in response to intracellular guanine- nucleotide depletion.
功能
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:
7903306, PubMed:
7763314). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:
14766016). It may also have a role in the development of malignancy and the growth progression of some tumors.
