产品名称
BANF1 (8E13) Rabbit Monoclonal Antibody
别名
BAF; BANF1; BCRG1; BCRP1; NGPS;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
O75531
免疫原
A synthetic peptide of human BANF1
稀释度
WB: 1:1000-1:5000 IHC: 1:20-1:100 ICC/IF: 1:20 FC: 1:50
注意事项
BANF1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed. Expressed in colon, brain, heart, kidney, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen and testis. Not detected in thymus and peripheral blood leukocytes
细胞定位
[Barrier-to-autointegration factor]: Nucleus. Cytoplasm. Chromosome. Nucleus envelope. Note=Significantly enriched at the nuclear inner membrane, diffusely throughout the nucleus during interphase and concentrated at the chromosomes during the M-phase. The phosphorylated form (by VRK1 or vaccinia virus B1 kinase) shows a cytoplasmic localization whereas the unphosphorylated form locates almost exclusively in the nucleus (PubMed:24600006, PubMed:16495336) May be included in HIV-1 virions via its interaction with viral GAG polyprotein.
功能
Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non- specific dsDNA-binding sites which may promote DNA cross-bridging.
