产品名称
NRN1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9NPD7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NPD7/entry
Mouse Swissprot No.
Q8CFV4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CFV4
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941O08957
免疫原
Synthesized peptide derived from human protein . at AA range: 40-120
特异性
NRN1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
组织表达
Adrenal cortex,Brain,Uterus,
细胞定位
Cell membrane ; Lipid-anchor, GPI-anchor . Cell junction, synapse .
功能
function:Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.,similarity:Belongs to the neuritin family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
