RM5935

GDF15 (6F3) Rabbit Monoclonal Antibody

GDF-15; growth differentiation factor 15; MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB;

Affinity-chromatography

常规抗体

GDF15

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

9518

Q99988

A synthetic peptide of human GDF15

WB: 1:1000

34kDa

34kDa

Rabbit IgG

GDF15 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney (PubMed:9348093) Detected in plasma (at protein level) (PubMed:28572090, PubMed:29046435).

Secreted

Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL- expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling (By similarity).

现货