产品名称
beta Defensin 1 (3G17) Rabbit Monoclonal Antibody
别名
BD1; beta 1; DEFB1; DEFB101; Defensin; Defensin beta 1; HBD1;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P60022
注意事项
beta Defensin 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Blood plasma. Sperm. Highly expressed in the lower head and midpiece of sperm. Significantly reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level).
细胞定位
Secreted. Membrane. Note=Associates with tumor cell membrane-derived microvesicles (PubMed:23938203)
功能
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:
25122636).
