RM5931

DMRT1 (13B8) Rabbit Monoclonal Antibody

CT154; dmrt1; DMT1;

Affinity-chromatography

常规抗体

DMRT1

DMT1

WB

Human

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

1761

Q9Y5R6

WB 1:500~1:2000 IP 1:80

39kDa

Rabbit IgG

DMRT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Testis-specific. Expressed in prostate cancer (at protein level).

Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.

Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).

现货