产品名称
Methionine Aminopeptidase 2 (2I14) Rabbit Monoclonal Antibody
别名
Amp2; MAP2; Metap2; MNPEP; p67; p67eIF2;
纯度
Affinity-chromatography
基因名称
METAP2 {ECO:0000255|HAMAP-Rule:MF_03175}
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P50579
免疫原
A synthetic peptide of human Methionine Aminopeptidase 2/p67
稀释度
WB: 1:1000 IHC: 1:50 ICC/IF: 1:50 FC: 1:20-1:100
注意事项
Methionine Aminopeptidase 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:21537465}. Note=About 30% of expressed METAP2 associates with polysomes
功能
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.
