产品名称
NRX1B Rabbit Polyclonal Antibody
蛋白名称
Neurexin-1-beta (Neurexin I-beta)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P58400
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P58400/entry
Mouse Swissprot No.
P0DI97
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P0DI97
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q63373
免疫原
Synthesized peptide derived from human protein . at AA range: 260-340
特异性
NRX1B Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
alternative products:A number of isoforms are produced by alternative promoter usage including the alpha-type (shown here) and beta-type (AC P58400) isoforms which differ in their N-terminus. Additional isoforms may be produced by alternative splicing,alternative products:A number of isoforms, alpha-type (AC Q9ULB1) and beta-type (shown here), are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus,function:Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling.,function:Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.,PTM:Highly O-glycosylated and minor N-glycosylated.,PTM:N- and O-glycosylated.,similarity:Belongs to the neurexin family.,similarity:Contains 1 laminin G-like domain.,similarity:Contains 3 EGF-like domains.,similarity:Contains 6 laminin G-like domains.,subunit:The cytoplasmic C-terminal region binds to CASK, CASKIN1 and APBA1. The laminin G-like domain 2 binds to NXPH1. Specific isoforms bind to alpha-dystroglycan and to alpha-latroxin. Interacts with SYT13 and SYTL1.,subunit:The cytoplasmic C-terminal region binds to CASK. Isoforms Beta 4b bind neuroligins NLGN1, NLGN2 and NLGN3, alpha-dystroglycan and alpha-latrotoxin.,tissue specificity:Heart and brain.,
细胞定位
Cell junction, synapse, presynaptic cell membrane ; Single-pass type I membrane protein .
信号通路
Cell adhesion molecules (CAMs);
功能
alternative products:A number of isoforms are produced by alternative promoter usage including the alpha-type (shown here) and beta-type (AC P58400) isoforms which differ in their N-terminus. Additional isoforms may be produced by alternative splicing,alternative products:A number of isoforms, alpha-type (AC Q9ULB1) and beta-type (shown here), are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus,function:Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling.,function:Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.,PTM:Highly O-glycosylated and minor N-glycosylated.,PTM:N- and O-glycosylated.,similarity:Belongs to the neurexin family.,similarity:Contains 1 laminin G-like domain.,similarity:Contains 3 EGF-like domains.,similarity:Contains 6 laminin G-like domains.,subunit:The cytoplasmic C-terminal region binds to CASK, CASKIN1 and APBA1. The laminin G-like domain 2 binds to NXPH1. Specific isoforms bind to alpha-dystroglycan and to alpha-latroxin. Interacts with SYT13 and SYTL1.,subunit:The cytoplasmic C-terminal region binds to CASK. Isoforms Beta 4b bind neuroligins NLGN1, NLGN2 and NLGN3, alpha-dystroglycan and alpha-latrotoxin.,tissue specificity:Heart and brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
