产品名称
FKBP52 (17D18) Rabbit Monoclonal Antibody
别名
HBI; p52; Hsp56; FKBP51; FKBP52; FKBP59; PPIase;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q02790
免疫原
A synthetic peptide of human FKBP52
稀释度
WB: 1:1000 IHC: 1:200
注意事项
FKBP52 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Cytoplasm, cytosol. Mitochondrion. Nucleus {ECO:0000250|UniProtKB:P30416}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QVC8}. Cell projection, axon {ECO:0000250|UniProtKB:Q9QVC8}. Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor (PubMed:21730050). Colocalized with MAPT/TAU in the distal part of the primary cortical neurons (By similarity) {ECO:0000250|UniProtKB:Q9QVC8, ECO:0000269|PubMed:21730050}
功能
Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
