产品名称
FKBP51 (19M9) Rabbit Monoclonal Antibody
别名
AIG6; FKBP5; FKBP51; FKBP54; P54; PPIase; PPIase FKBP5; Ptg10;Rotamase;
纯度
Affinity-chromatography
蛋白名称
AIG6, FKBP51 {ECO:0000303|PubMed:2814727
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q13451
免疫原
A synthetic peptide of human FKBP51
稀释度
WB: 1:1000 IHC: 1:20 ICC/IF: 1:20 FC: 1:20 IP: 1:20
注意事项
FKBP51 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed, enriched in testis compared to other tissues
细胞定位
Cytoplasm {ECO:0000250|UniProtKB:Q64378}. Nucleus {ECO:0000250|UniProtKB:Q64378}
功能
Immunophilin protein with PPIase and co-chaperone activities (PubMed:
11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:
12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:
28147277).
