RM5919

CD35 (4U8) Rabbit Monoclonal Antibody

C3 binding protein; C3b/C4b receptor; C3BR; C4BR; CD35; CR1; KN;

Affinity-chromatography

常规抗体

CR1

C3BR

WB

Human

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

1378

P17927

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

224kDa

Rabbit IgG

CD35 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Present on erythrocytes, a subset of T cells, mature B cells, follicular dendritic cells, monocytes and granulocytes

Membrane; Single- pass type I membrane protein

Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069). Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation (PubMed:2963069). Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d (PubMed:2972794, PubMed:8175757). Plays also a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells (PubMed:25742728).

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