产品名称
MC1 Receptor (9V10) Rabbit Monoclonal Antibody
别名
CMM5; MC1R; MSHR; SHEP2;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q01726
稀释度
WB 1:500~1:2000 IHC 1:100~1:500
注意事项
MC1 Receptor Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in melanocytes (PubMed:1325670, PubMed:31097585). Expressed in corticoadrenal tissue (PubMed:1325670)
细胞定位
Cell membrane; Multi-pass membrane protein
功能
Receptor for MSH (alpha, beta and gamma) and ACTH (PubMed:
1325670, PubMed:
8463333, PubMed:
1516719, PubMed:
11442765, PubMed:
11707265). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:
1325670, PubMed:
11707265, PubMed:
16463023, PubMed:
19737927). Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (PubMed:
31097585).
