产品名称
FKBP51 (19M9) Rabbit Monoclonal Antibody
别名
AIG6; FKBP5; FKBP51; FKBP54; P54; PPIase; PPIase FKBP5; Ptg10;Rotamase;
纯度
Affinity-chromatography
蛋白名称
AIG6, FKBP51 {ECO:0000303|PubMed:2814727
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q13451
免疫原
A synthetic peptide of human FKBP51
注意事项
FKBP51 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed, enriched in testis compared to other tissues
细胞定位
Cytoplasm {ECO:0000250|UniProtKB:Q64378}. Nucleus {ECO:0000250|UniProtKB:Q64378}
功能
Immunophilin protein with PPIase and co-chaperone activities (PubMed:
11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:
12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:
28147277).
