产品名称
CHL1 Rabbit Polyclonal Antibody
蛋白名称
Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein]
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O00533
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O00533/entry
Mouse Swissprot No.
P70232
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P70232
免疫原
Synthesized peptide derived from human protein . at AA range: 140-220
特异性
CHL1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Nov 2011],
组织表达
Expressed in the fetal and adult brain as well as in Schwann cell culture. Also detected in adult peripheral tissues.
细胞定位
Cell membrane ; Single-pass type I membrane protein . Soluble forms produced by cleavage/shedding also exist. .; [Processed neural cell adhesion molecule L1-like protein]: Secreted, extracellular space, extracellular matrix .
功能
disease:The deletion of 1 copy of the CHL1 may be responsible for mental defects in patients with 3p- syndrome. 3p- syndrome results from deletion of a terminal segment of the short arm of one chromosome 3 and is characterized by multiple congenital anomalies and mental retardation.,domain:The DGEA motif seems to be a recognition site for integrin.,domain:The FIG[AQ]Y motif seems to be an ankyrin recruitment region.,function:Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane.,PTM:Cleavage by metalloprotease ADAM8 in the extracellular part generates 2 soluble forms (125 kDa and 165 kDa) in vitro and is inhibited by metalloprotease inhibitors.,PTM:N-glycosylated. Contains N-linked oligosaccharides with a sulfated carbohydrate structure type HNK-1 (SO4-3-GlcUABeta1,3GalBeta1,4GlcNAc).,PTM:O-glycosylated.,similarity:Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.,similarity:Contains 4 fibronectin type-III domains.,similarity:Contains 6 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Soluble forms produced by cleavage/shedding also exist.,subunit:May interact with L1CAM. May interact with ITGB1/ITGA1 heterodimer and ITGB1/ITGA2 heterodimer as well as with ANK3.,tissue specificity:Expressed in the fetal and adult brain as well as in Schwann cell culture. Also detected in adult peripheral tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
