Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:
15448697, PubMed:
14739464, PubMed:
16260596, PubMed:
16482215, PubMed:
17079684, PubMed:
16407242, PubMed:
16407252, PubMed:
16940174). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV- induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:
15448697, PubMed:
16260596, PubMed:
16407242, PubMed:
16940174). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (PubMed:
15448697, PubMed:
16260596, PubMed:
16407242, PubMed:
16940174). Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:
14739464, PubMed:
16407252, PubMed:
16482215, PubMed:
17079684, PubMed:
25043012, PubMed:
25108355, PubMed:
18332868, PubMed:
18381890, PubMed:
19966799, PubMed:
22118460, PubMed:
28886238). The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1 (PubMed:
14739464, PubMed:
16407252, PubMed:
16482215, PubMed:
17079684, PubMed:
25043012, PubMed:
25108355, PubMed:
18332868, PubMed:
18381890, PubMed:
19966799, PubMed:
22118460). DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV- induced DNA damage (PubMed:
16678110, PubMed:
17041588, PubMed:
16473935, PubMed:
18593899). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (PubMed:
16678110, PubMed:
17041588, PubMed:
16473935, PubMed:
18593899). DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (PubMed:
15882621). DCX(DTL) plays a role in PCNA- dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication (PubMed:
17041588). DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR) (PubMed:
12732143). The DDB1- CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:
26431207). DDB1-mediated CRY1 degradation promotes FOXO1 protein stability and FOXO1-mediated gluconeogenesis in the liver (By similarity).
