RM5896

IL23 (1X13) Rabbit Monoclonal Antibody

IL 23A; IL 23p19; IL12B; IL23; Il23a; IL23P19; P19; SGRF;

Affinity-chromatography

常规抗体

IL23A

SGRF

WB

Human

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

51561

Q9NPF7

WB 1:500~1:1000

21kDa

Rabbit IgG

IL23 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).

Secreted. Note=Secreted upon association with IL12B

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

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