产品名称
Netrin 1 (8Q2) Rabbit Monoclonal Antibody
别名
Netrin1; NTN1; NTN1L; Unc6;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
O95631
稀释度
WB 1:500~1:2000 ICC/IF 1:50~1:200
注意事项
Netrin 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein level).
细胞定位
Secreted. Cytoplasm. Note=Mainly secreted
功能
Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:
28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:
28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis (PubMed:
15343335).
