BD-PN0946

UNC5C Rabbit Polyclonal Antibody

常规抗体

UNC5C UNC5H3

Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C)

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

8633

O95185

https://www.uniprot.org/uniprotkb/O95185/entry

O08747

http://www.uniprot.org/uniprot/O08747

Q761X5

http://www.uniprot.org/uniprot/O54941Q761X5

Synthesized peptide derived from human protein . at AA range: 60-140

UNC5C Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

102kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008],

Mainly expressed in brain (PubMed:9782087). Expressed in temporal lobe cortical neurons and in neurons of the hippocampal pyramidal layer (PubMed:25419706). Also expressed in kidney (PubMed:9782087). Not expressed in developing or adult lung (PubMed:9782087).

Cell membrane ; Single-pass type I membrane protein . Cell surface . Cell junction, synapse, synaptosome . Cell projection, axon . Cell projection, dendrite . Cell projection, growth cone . Cell projection, lamellipodium . Cell projection, filopodium .

Axon guidance;

function:Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.,miscellaneous:Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.,PTM:Phosphorylated on different cytoplasmic tyrosine residues. Phosphorylation of Tyr-568 leads to an interaction with PTPN11 phosphatase, suggesting that its activity is regulated by phosphorylation/dephosphorylation. Tyrosine phosphorylation is netrin-dependent.,PTM:Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.,similarity:Belongs to the unc-5 family.,similarity:Contains 1 death domain.,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 ZU5 domain.,similarity:Contains 2 TSP type-1 domains.,subunit:Interacts with the cytoplasmic part of DCC.,tissue specificity:Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.