RM5865

GRIM19 (3Y1) Rabbit Monoclonal Antibody

B16.6; CDA016; CGI-39; GRIM19; GRIM-19;

Affinity-chromatography

常规抗体

NDUFA13

GRIM19

WB

Human

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

51079

Q9P0J0

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

17kDa

Rabbit IgG

GRIM19 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis.

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Nucleus Note=Localizes mainly in the mitochondrion (PubMed:12628925). May be translocated into the nucleus upon IFN/RA treatment

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371). Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091).

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