BD-PN0944

UNC5A Rabbit Polyclonal Antibody

常规抗体

UNC5A KIAA1976 UNC5H1

Netrin receptor UNC5A (Protein unc-5 homolog 1) (Protein unc-5 homolog A)

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

90249

Q6ZN44

https://www.uniprot.org/uniprotkb/Q6ZN44/entry

Q8K1S4

http://www.uniprot.org/uniprot/Q8K1S4

O08721

http://www.uniprot.org/uniprot/O54941O08721

Synthesized peptide derived from human protein . at AA range: 130-210

UNC5A Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

92kD

-20°C/1 year

Polyclonal, Rabbit,IgG

UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004],

Brain,PCR rescued clones,Pooled,

Cell membrane ; Single-pass type I membrane protein . Membrane raft . Cell projection, neuron projection . The interaction with PRKCABP regulates its surface expression and leads to its removal from the surface of neurons and growth cones. .

Axon guidance;

domain:The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis.,function:Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.,induction:By p53/TP53.,miscellaneous:Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.,PTM:Phosphorylated on cytoplasmic tyrosine residues. Phosphorylated by PKC in vitro.,PTM:Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.,sequence caution:Intron retention.,similarity:Belongs to the unc-5 family.,similarity:Contains 1 death domain.,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 TSP type-1 domain.,similarity:Contains 1 ZU5 domain.,subcellular location:The interaction with PRKCABP regulates its surface expression and leads to its removal from surface of neurons and growth cones.,subunit:Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly mediating some interaction with PKC.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.