RM5846

Creatine kinase B type (12W4) Rabbit Monoclonal Antibody

BCK; Ckb; CKBB; HEL 211; HEL S 29;

Affinity-chromatography

常规抗体

CKB

CKBB

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

1152

P12277

A synthetic peptide of human Creatine kinase B type

WB: 1:2000-1:10000 IHC: 1:20-1:100 ICC/IF: 1:20-1:100 FC: 1:20

43kDa

43kDa

Rabbit IgG

Creatine kinase B type Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q04447}. Mitochondrion {ECO:0000250|UniProtKB:Q04447}. Note=Localizes to the mitochondria of thermogenic fat cells via the internal MTS-like signal (iMTS-L) region {ECO:0000250|UniProtKB:Q04447}

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N- phosphocreatine as heat without performing any mechanical or chemical work (By similarity).

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