产品名称
RbAp48 (2V2) Rabbit Monoclonal Antibody
别名
CAF I p48; CAF-I p48; NURF55; RBAP48; RBBP4;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q09028
免疫原
A synthetic peptide of human RbAp48
稀释度
WB: 1:2000-1:10000 IHC: 1:20 ICC/IF: 1:20 FC: 1:20 IP: 1:20
注意事项
RbAp48 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Nucleus Note=Localizes to chromatin as part of the PRC2 complex
功能
Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
