产品名称
SOCS2 (3T6) Rabbit Monoclonal Antibody
别名
CIS2; Cish2; Socs2; SSI2; STATI2;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
O14508
免疫原
A synthetic peptide of human SOCS2
稀释度
WB: 1:1000-1:5000 ICC/IF: 1:20-1:50 IP: 1:20-1:50
注意事项
SOCS2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
High expression in heart, placenta, lung, kidney and prostate. Predominantly expressed in pulmonary epithelia cells, specifically type II pneumocytes.
功能
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
