产品名称
Nicastrin (16C3) Rabbit Monoclonal Antibody
别名
APH2; Ncstn; NCT; Nicastrin;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q92542
免疫原
A synthetic peptide of human Nicastrin
稀释度
WB: 1:1000 FC: 1:20 IP: 1:20
注意事项
Nicastrin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Detected in brain (at protein level) (PubMed:10993067). Widely expressed (PubMed:11396676)
细胞定位
Membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
功能
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein) (PubMed:
10993067, PubMed:
12679784, PubMed:
25043039, PubMed:
26280335, PubMed:
30598546, PubMed:
30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.
