RM5798

KAT13A / SRC1 (1Z1) Rabbit Monoclonal Antibody

bHLHe74; mNRC 1; NCoA 1; RIP160; SRC 1;

Affinity-chromatography

常规抗体

NCOA1

BHLHE74, SRC1

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

8648

Q15788

Recombinant protein of human SRC1

WB: 1:1000 IHC: 1:50 IP: 1:20

157kDa

157kDa

Rabbit IgG

KAT13A / SRC1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Widely expressed.

Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.

现货