产品名称
KDM4A (16A5) Rabbit Monoclonal Antibody
别名
JHDM3A; JMJD2; JMJD2A; KDM4A; TDRD14A;
纯度
Affinity-chromatography
蛋白名称
JHDM3A, JMJD2, JMJD2A, KIAA0677
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
O75164
免疫原
A synthetic peptide of human KDM4A/JHDM3A/JMJD2A
稀释度
WB: 1:2000 IHC: 1:50 IP: 1:20
注意事项
KDM4A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:15927959, ECO:0000269|PubMed:16024779}
功能
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:
26741168). Does not demethylate histone H3 'Lys- 4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.
