RM5794

SF3B3 (2I12) Rabbit Monoclonal Antibody

RSE1; SAP130; SF3b130; STAF130;

Affinity-chromatography

常规抗体

SF3B3

KIAA0017, SAP130 {ECO:0000303|PubMed:104

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

23450

Q15393

A synthetic peptide of human SF3B3

WB: 1:1000 IHC: 1:500 ICC/IF: 1:50 FC: 1:50

136kDa

136kDa

Rabbit IgG

SF3B3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Nucleus

Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:10490618, PubMed:10882114, PubMed:27720643, PubMed:28781166). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077).

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