产品名称
FHL2 (4I16) Rabbit Monoclonal Antibody
别名
AAG11; DRAL; Fhl2; SLIM3;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q14192
稀释度
WB 1:500~1:1000 ICC/IF 1:50~1:200 IP 1:40
注意事项
FHL2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in skeletal muscle and heart.
细胞定位
Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:O35115}
功能
May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:
28717008).
