产品名称
NKX3.1 (9R11) Rabbit Monoclonal Antibody
别名
NKX3; BAPX2; NKX3A; NKX3.1; NKX3-1;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q99801
稀释度
WB 1:500~1:1000 IHC 1:50~1:200
注意事项
NKX3.1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Highly expressed in the prostate and, at a lower level, in the testis.
细胞定位
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:11137288}
功能
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
