BD-PN0936

NU2M Rabbit Polyclonal Antibody

常规抗体

MT-ND2 MTND2 NADH2 ND2

NADH-ubiquinone oxidoreductase chain 2 (EC 1.6.5.3) (NADH dehydrogenase subunit 2)

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

4536

P03891

https://www.uniprot.org/uniprotkb/P03891/entry

P03893

http://www.uniprot.org/uniprot/P03893

P11662

http://www.uniprot.org/uniprot/O54941P11662

Synthesized peptide derived from human protein . at AA range: 40-120

NU2M Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

38kD

-20°C/1 year

Polyclonal, Rabbit,IgG

catalytic activity:NADH + ubiquinone = NAD(+) + ubiquinol.,disease:Defects in MT-ND2 are a cause of Leber hereditary optic neuropathy (LHON) [MIM:535000]. LHON is a maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes.,disease:Defects in MT-ND2 may be associated with mitochondrial susceptibility to Alzheimer disease (AD) [MIM:502500].,function:Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.,similarity:Belongs to the complex I subunit 2 family.,

Blood,Bone fossil,Bones,Breast cancer,Distant normal tissue,Glioma,Para-cancerous normal tissue,Pla

Mitochondrion inner membrane ; Multi-pass membrane protein .

Oxidative phosphorylation;Parkinson's disease;

catalytic activity:NADH + ubiquinone = NAD(+) + ubiquinol.,disease:Defects in MT-ND2 are a cause of Leber hereditary optic neuropathy (LHON) [MIM:535000]. LHON is a maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes.,disease:Defects in MT-ND2 may be associated with mitochondrial susceptibility to Alzheimer disease (AD) [MIM:502500].,function:Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.,similarity:Belongs to the complex I subunit 2 family.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.