产品名称
SIRP alpha (14C14) Rabbit Monoclonal Antibody
别名
CD172a; MFR; MYD 1; p84; PTPNS1; SHPS1; SIRP; SIRPA; SIRPalpha; SIRPalpha1; SIRPalpha2; SIRPalpha3;
纯度
Affinity-chromatography
蛋白名称
BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P78324
免疫原
Recombinant protein of human SIRP alpha
注意事项
SIRP alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas
细胞定位
Membrane; Single-pass type I membrane protein.
功能
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
