产品名称
NKX3.1 (9R11) Rabbit Monoclonal Antibody
别名
NKX3; BAPX2; NKX3A; NKX3.1; NKX3-1;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q99801
注意事项
NKX3.1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Highly expressed in the prostate and, at a lower level, in the testis.
细胞定位
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:11137288}
功能
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
