产品名称
NB5R2 Rabbit Polyclonal Antibody
蛋白名称
NADH-cytochrome b5 reductase 2 (b5R.2) (EC 1.6.2.2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q6BCY4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6BCY4/entry
Mouse Swissprot No.
Q3KNK3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3KNK3
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q6AY12
免疫原
Synthesized peptide derived from human protein . at AA range: 120-200
特异性
NB5R2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the flavoprotein pyridine nucleotide cytochrome reductase family of proteins. Cytochrome b-type NAD(P)H oxidoreductases are implicated in many processes including cholesterol biosynthesis, fatty acid desaturation and elongation, and respiratory burst in neutrophils and macrophages. Cytochrome b5 reductases have soluble and membrane-bound forms that are the product of alternative splicing. In animal cells, the membrane-bound form binds to the endoplasmic reticulum, where it is a member of a fatty acid desaturation complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014],
组织表达
Restricted expression.
细胞定位
nucleus,mitochondrion,endoplasmic reticulum membrane,membrane,integral component of membrane,
功能
catalytic activity:NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5.,cofactor:FAD.,function:NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1).,similarity:Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.,similarity:Contains 1 FAD-binding FR-type domain.,tissue specificity:Restricted expression.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
