产品名称
Furin (6Z15) Rabbit Monoclonal Antibody
别名
FUR; FURIN; PACE; PCSK3; SPC1;
纯度
Affinity-chromatography
基因名称
FURIN {ECO:0000303|PubMed:7690548, ECO:0000312|HGNC:HGNC:8568}
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P09958
稀释度
WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200
注意事项
Furin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Seems to be expressed ubiquitously.
细胞定位
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Secreted. Endosome membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface (PubMed:9412467, PubMed:11799113). Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin (PubMed:11799113)
功能
Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:
11799113, PubMed:
1629222, PubMed:
1713771, PubMed:
2251280, PubMed:
24666235, PubMed:
25974265, PubMed:
7592877, PubMed:
7690548, PubMed:
9130696). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (PubMed:
7737999). Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-32) (PubMed:
20489134, PubMed:
21763278).
