RM5750

Geminin (2T3) Rabbit Monoclonal Antibody

Gem; Geminin; GMNN;

Affinity-chromatography

常规抗体

GMNN

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

51053

O75496

Recombinant protein of human Geminin

WB: 1:1000 IHC: 1:50 ICC/IF: 1:20

24kDa

24kDa

Rabbit IgG

Geminin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Cytoplasm. Nucleus. Note=Mainly cytoplasmic but can be relocalized to the nucleus.

Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) (PubMed:9635433, PubMed:14993212, PubMed:20129055, PubMed:24064211). It is degraded during the mitotic phase of the cell cycle (PubMed:9635433, PubMed:14993212, PubMed:24064211). Its destruction at the metaphase- anaphase transition permits replication in the succeeding cell cycle (PubMed:9635433, PubMed:14993212, PubMed:24064211). Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing (PubMed:20129055). Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control (PubMed:22615398).

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