RM5740

E1 Ubiquitin Activating Enzyme (7R17) Rabbit Monoclonal Antibody

A1S9; A1S9T; A1ST; AMCX1; CFAP124; GXP1; POC20; SMAX2; Uba1; UBA1A; UBE1; UBE1X;

Affinity-chromatography

常规抗体

UBA1

A1S9T, UBE1

WB

Human,Mouse,Rat

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

7317

P22314

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1:50

118kDa

Rabbit IgG

E1 Ubiquitin Activating Enzyme Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Detected in erythrocytes (at protein level). Ubiquitous.

Cytoplasm. Mitochondrion. Nucleus [Isoform 2]: Cytoplasm

Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1606621, PubMed:1447181, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334).

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