产品名称
Furin (6Z15) Rabbit Monoclonal Antibody
别名
FUR; FURIN; PACE; PCSK3; SPC1;
纯度
Affinity-chromatography
基因名称
FURIN {ECO:0000303|PubMed:7690548, ECO:0000312|HGNC:HGNC:8568}
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P09958
注意事项
Furin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Seems to be expressed ubiquitously.
细胞定位
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Secreted. Endosome membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface (PubMed:9412467, PubMed:11799113). Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin (PubMed:11799113)
功能
Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:
11799113, PubMed:
1629222, PubMed:
1713771, PubMed:
2251280, PubMed:
24666235, PubMed:
25974265, PubMed:
7592877, PubMed:
7690548, PubMed:
9130696). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (PubMed:
7737999). Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-32) (PubMed:
20489134, PubMed:
21763278).
