产品名称
DCP1A (1Q16) Rabbit Monoclonal Antibody
别名
Dcp1a; HSA275986; Nbla00360; SMAD4IP1; SMIF;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q9NPI6
稀释度
WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1:100
注意事项
DCP1A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.
细胞定位
Cytoplasm, P-body. Nucleus. Note=Co- localizes with NANOS3 in the processing bodies (By similarity) Predominantly cytoplasmic, in processing bodies (PB) (PubMed:16364915) Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 (PubMed:11836524) {ECO:0000250|UniProtKB:Q91YD3, ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:16364915}
功能
Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:
12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (PubMed:
12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:
11836524). Essential for embryonic development (PubMed:
33813271).
