产品名称
TRBP (8B1) Rabbit Monoclonal Antibody
别名
LOQS; Prbp; tarbp2; TRBP; TRBP1; TRBP2;
纯度
Affinity-chromatography
基因名称
TARBP2 {ECO:0000255|HAMAP-Rule:MF_03034}
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q15633
免疫原
A synthetic peptide of human TRBP
稀释度
WB: 1:1000 IHC: 1:50 ICC/IF: 1:20 FC: 1:20 IP: 1:20
注意事项
TRBP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Cytoplasm. Cytoplasm, perinuclear region. Nucleus
功能
Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
