RM5717

TRP1 (8L13) Rabbit Monoclonal Antibody

CAS2; CATB; GP75; OCA3; TRP1;TYRP; TYRP1; TYRRP;

Affinity-chromatography

常规抗体

TYRP1

CAS2 {ECO:0000303|PubMed:1906272}, TYRP,

WB

Human

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

7306

P17643

WB 1:500~1:2000 IHC 1:50~1:200 IP 1:50

61kDa

Rabbit IgG

TRP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Pigment cells.

Melanosome membrane {ECO:0000250|UniProtKB:P07147}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P07147}. Melanosome {ECO:0000250|UniProtKB:P07147}. Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38 {ECO:0000250|UniProtKB:P07147}

Plays a role in melanin biosynthesis (PubMed:22556244, PubMed:16704458). Catalyzes the oxidation of 5,6-dihydroxyindole-2- carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+) (PubMed:28661582). May regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity).

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