产品名称
Nuf2 (16U18) Rabbit Monoclonal Antibody
别名
CDCA1; CT106; hNuf2; hNuf2R; hsNuf2; NUF2; NUF2R;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q9BZD4
免疫原
A synthetic peptide of human Nuf2
稀释度
WB: 1:1000-1:5000 IHC: 1:100-1:500 ICC/IF: 1:100 FC: 1:20
注意事项
Nuf2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase Localizes specifically to the outer plate of the kinetochore. NDC80 is required for efficient kinetochore localization
功能
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:
12438418, PubMed:
14654001, PubMed:
15062103, PubMed:
15235793, PubMed:
15239953, PubMed:
15548592, PubMed:
17535814). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:
15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:
23085020).
