产品名称
ELMO1 (12B1) Rabbit Monoclonal Antibody
别名
CED12; Ced12 homolog 1; ELMO 1;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q92556
免疫原
A synthetic peptide of human ELMO1
稀释度
WB: 1:5000 ICC/IF: 1:50 FC: 1:20 IP: 1:20
注意事项
ELMO1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Widely expressed, with a higher expression in the spleen and placenta
细胞定位
Cytoplasm. Cell membrane. Note=Translocation to plasma membrane seems to be mediated by DOCK1 and CRK
功能
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
