产品名称
NOXO1 Rabbit Polyclonal Antibody
基因名称
NOXO1 P41NOX SH3PXD5
蛋白名称
NADPH oxidase organizer 1 (NADPH oxidase regulatory protein) (Nox organizer 1) (Nox-organizing protein 1) (SH3 and PX domain-containing protein 5)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8NFA2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8NFA2/entry
Mouse Swissprot No.
Q8VCM2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VCM2
免疫原
Synthesized peptide derived from human protein . at AA range: 160-240
特异性
NOXO1 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an NADPH oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. The protein contains a PX domain and two SH3 domains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012],
组织表达
Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis.
细胞定位
[Isoform 3]: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Isoform 3 associates with the plasma membrane in a lipid-dependent manner (PubMed:12716910).
功能
developmental stage:Isoform 3 is expressed in fetal liver.,domain:The PX domain mediates lipid-binding, localization to the plasma membrane and is required for NOX1 activation.,domain:The SH3 domains mediate interaction with CYBA/p22phox. Also mediates intramolecular interaction with the proline-rich region.,function:Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 2 SH3 domains.,subcellular location:Isoform 3 associates with the plasma membrane in a lipid-dependent manner.,subunit:Interacts with NOX1, NOXA1, CYBA/p22phox and NCF2/p67phox.,tissue specificity:Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
