产品名称
Serotonin transporter (17O19) Rabbit Monoclonal Antibody
别名
SLC6A4; 5HTT; 5HT transporter; 5-HTT; 5-HTTLPR; OCD1; SERT; Serotonin transporter; HSERT; SERT1;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P31645
注意事项
Serotonin transporter Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in platelets (at protein level).
细胞定位
Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7K4Y6, ECO:0000269|PubMed:27049939}. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi- pass membrane protein. Cell junction, synapse {ECO:0000250|UniProtKB:Q60857}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q60857}. Note=Could be part of recycling endosomes (PubMed:16870614). Density of transporter molecules on the plasma membrane is itself regulated by STX1A (By similarity). Density of transporter molecules on the plasma membrane is also regulated by serotonin (PubMed:17506858). Density of transporter molecules seems to be modulated by ITGAV:ITGB3 (By similarity) {ECO:0000250|UniProtKB:P31652, ECO:0000250|UniProtKB:Q60857, ECO:0000269|PubMed:16870614, ECO:0000269|PubMed:17506858}
功能
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
