RM5683

SF3B1 (13E17) Rabbit Monoclonal Antibody

Hsh 155; MDS; PRP10; PRPF10; SAP155; SF3B 1; SF3b155;

Affinity-chromatography

常规抗体

SF3B1

SAP155

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

23451

O75533

A synthetic peptide of human SF3B1

WB: 1:1000 IHC: 1:50 ICC/IF: 1:50 FC: 1:200

155kDa

146kDa

Rabbit IgG

SF3B1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Nucleus. Nucleus speckle. Note=During mitosis, transiently dispersed from the nuclear speckles to the cytoplasm

Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077).

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