RM5675

E2F6 (1Y2) Rabbit Monoclonal Antibody

E2F 6; E2F-6; E2F6; EMA;

Affinity-chromatography

常规抗体

E2F6 {ECO:0000303|PubMed:9689056, ECO:0000312|HGNC:HGNC:3120}

WB

Human

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

1876

O75461

WB 1:500~1:2000 ICC/IF 1:50~1:200 FC 1:50

32kDa

Rabbit IgG

E2F6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed in all tissues examined. Highest levels in placenta, skeletal muscle, heart, ovary, kidney, small intestine and spleen.

Nucleus

Inhibitor of E2F-dependent transcription (PubMed:9689056, PubMed:9704927, PubMed:9501179). Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' (PubMed:9501179). Has a preference for the 5'-TTTCCCGC-3' E2F recognition site (PubMed:9501179). E2F6 lacks the transcriptional activation and pocket protein binding domains (PubMed:9704927, PubMed:9501179). Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression (PubMed:9689056, PubMed:9501179). Represses expression of some meiosis-specific genes, including SLC25A31/ANT4 (By similarity). May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (PubMed:9501179).

现货