RM5665

GABA A Receptor beta 2 (8H18) Rabbit Monoclonal Antibody

GABA; GABA(A) receptor beta 2; GABA(A) receptor subunit beta-2; GABRB2;

Affinity-chromatography

常规抗体

GABRB2

WB

Human,Mouse,Rat

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

2561

P47870

WB 1:500~1:2000

59kDa

Rabbit IgG

GABA A Receptor beta 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.

Cell junction, synapse, postsynaptic cell membrane {ECO:0000250|UniProtKB:P63137}; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P63138}

Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:8264558, PubMed:19763268, PubMed:27789573, PubMed:29950725). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).

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