产品名称
Exportin2 (10F6) Rabbit Monoclonal Antibody
别名
CSE1L; CAS; CSE1; Exp2; Importin-alpha re-exporter; Exportin-2; XPO2;
纯度
Affinity-chromatography
蛋白名称
CAS {ECO:0000303|PubMed:7479798}, XPO2
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P55060
免疫原
A synthetic peptide of human Cellular Apoptosis Susceptibility
稀释度
WB: 1:1000-1:5000 IHC: 1:50 ICC/IF: 1:100 FC: 1:20
注意事项
Exportin2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Detected in brain, placenta, ovary, testis and trachea (at protein level) (PubMed:10331944). Widely expressed (PubMed:10331944). Highly expressed in testis and in proliferating cells (PubMed:7479798,PubMed:10331944).
细胞定位
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
功能
Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
