Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein) (PubMed:
15274632, PubMed:
10545183, PubMed:
10593990, PubMed:
10206644, PubMed:
10899933, PubMed:
10811883, PubMed:
12679784, PubMed:
12740439, PubMed:
25043039, PubMed:
26280335, PubMed:
30598546, PubMed:
30630874, PubMed:
28269784, PubMed:
20460383). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed:
15274632, PubMed:
25043039, PubMed:
26280335, PubMed:
30598546, PubMed:
30630874). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:
9738936, PubMed:
10593990, PubMed:
10899933, PubMed:
10811883). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:
11953314). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed:
11953314). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed:
9738936, PubMed:
11953314). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (PubMed:
17428795, PubMed:
28269784). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis (PubMed:
25394380, PubMed:
16959576). Involved in the regulation of neurite outgrowth (PubMed:
15004326, PubMed:
20460383). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (By similarity).
