产品名称
Exportin2 (10F6) Rabbit Monoclonal Antibody
别名
CSE1L; CAS; CSE1; Exp2; Importin-alpha re-exporter; Exportin-2; XPO2;
纯度
Affinity-chromatography
蛋白名称
CAS {ECO:0000303|PubMed:7479798}, XPO2
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P55060
免疫原
A synthetic peptide of human Cellular Apoptosis Susceptibility
注意事项
Exportin2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Detected in brain, placenta, ovary, testis and trachea (at protein level) (PubMed:10331944). Widely expressed (PubMed:10331944). Highly expressed in testis and in proliferating cells (PubMed:7479798,PubMed:10331944).
细胞定位
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
功能
Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
